abstract |
(57) [Summary] [Purpose] 1, which is useful as a synthetic intermediate for musk-based flavors 1,3,4,4,6-hexamethyltetralin is produced in good yield. [Structure] An organometallic compound prepared from 2-chloropropane and 2-oxa-4-methyl-4-tolylpentane are subjected to an addition reaction in the presence of cerium chloride to produce 2, Cyclize 3,5-trimethyl-3-hydroxy-5-tolylhexane in the presence of sulfuric acid. |