| abstract |
(57) [Summary] (Modified) [Structure] General formula H-X ↑ 1-Cys-ABBABA-Ser-X ↑ 2-Y (In the formula, A is an amino acid residue Val. , Leu, Ile, Nle, B Is the amino acid residues Arg, Lys, Gln, His, Ser, X ↑ 1 And X ↑ 2 is a single bond or Gly, Ala, Val, Arg, Asn, Ser, Phe, Pro, Leu, Glu, Asp, Lys, Th A peptide fragment consisting of 1 to 10 amino acid residues selected from r, His, Tyr, Nle, and Ile, Y is a hydroxyl group or an amino group), and has a human interleukin-1 binding ability or a salt thereof. A therapeutic agent for osteoporosis containing as an active ingredient. [Effect] It is useful for treatment of osteoporosis associated with IL-1, such as para-articular osteoporosis associated with rheumatoid arthritis, alveolar bone resorption associated with periodontitis, postmenopausal high-rotation osteoporosis, and senile osteoporosis. |