| abstract |
(57) [Summary] [Structure] A novel substance, a sialic acid oligosaccharide derivative represented by the following formula (I), and a fine particle carrier such as a liposome containing it as a constituent. [Chemical 1] In the formula, X represents O or S, W represents a specific monosaccharide or disaccharide residue, m represents an integer of 1 to 8, and R 0 represents N 3 or N. H 2 or NHR (wherein R represents a linear or branched fatty acid carbonyl group, benzyloxycarbonyl group, t-butoxycarbonyl group or trimethylsilyl group), R 1 represents H, a lower alkyl group or It represents an alkali metal, R 2 to R 4 may be the same or different and each represents H or a hydroxyl-protecting group, and R 5 represents OH, OAc or H. [Effect] It is remarkable that such a fine particle carrier is hardly captured by the reticuloendothelial system. |