| abstract |
(57) [Summary] (Modified) [Objective] The present invention provides a prophylactic and therapeutic agent for osteoporosis, which has a novel estrogen compound that selectively acts on bone tissue as an active ingredient and has a high therapeutic effect and few side effects. [Structure] General formula (1) (E is a residue of estrogen, R 1 is a single bond or lower alkylene, R 2 is lower alkylene, lower alkenylene or lower alkynylene, R 3 is hydrogen atom or lower alkyl group, R 4 is hydroxyl group, lower alkyl group or lower alkoxy. Group, Y 1 is a single bond, —O—, —S (O) n — (n Represents 0, 1 or 2), —NR 5 — (R 5 represents a hydrogen atom or a lower alkyl group) or —CONR 6 — (R 6 represents a hydrogen atom or a lower alkyl group), Z 1 Is a single bond, -O -, - S- or -NH-, Z 2 represents a hydrogen atom, a lower alkyl group, a lower alkylthio group, a hydroxyl group or an amino group. However, when Z 1 is —O—, —S— or —NH—, R 2 is C 2 or higher lower alkylene, Z 2 represents a hydrogen atom. ), Pharmaceutically acceptable non-toxic salts and esters thereof. |