| abstract |
(57) [Summary] (Modified) [Constitution] General formula (I): [In the formula, R 1 and R 2 are H or C 1-6 -alkyl, or one of them is NH 2 ; R 3 and R 4 are H, C 3-6 -cycloalkyl, (substituted ) Alkenyl and the like; R 5 is (substituted) quinolin-5-yl, (substituted) Quinolin-8-yl, (halo-substituted) thiophen-2-yl, (halo-substituted) thiophen-3-yl, and X is O, -NH-]] arylquinolyl-substituted 1,4- A medicament comprising a dihydropyridine dicarboxylic acid derivative, and a physiologically acceptable salt thereof, and a compound of formula (I). The compound of the present invention can be used for the manufacture of a medicament for treating pathologically altered blood pressure and heart failure, and a therapeutic agent for coronary blood vessels. |