| abstract |
(57) [Summary] (Modified) [Structure] Expression [Wherein Ar 1 represents phenyl or naphthyl, a 10-membered bicyclic heterocyclic group, A 1 represents a direct bond to X 1 or C 1 -C 3 alkylene; X 1 is oxy, Thio, sulfinyl or sulfonyl; n represents 0, 1 or 2; R 1 represents halogeno, alkoxy or (fluoro) alkyl; R 2 , R 3 represents Represents an alkyl, alkenyl or alkynyl; and R 4 represents hydrogen or alkyl] or a pharmaceutically acceptable salt thereof, a process for the preparation thereof, a pharmaceutical composition thereof. The compounds are mediated alone or in part by one or more leukotrienes, eg allergic conditions, psoriasis, asthma, cardiovascular and cerebrovascular disorders, And / or are effective as therapeutic agents in the treatment of inflammation and arthritic conditions. |