| abstract |
(57) [Summary] (Modified) [Structure] A compound represented by the general formula (1) or a salt thereof. (In formula 1, k is 0-20: m is 0, 1: n is 4-29: X is OH, methyl, C 1-4 alkoxy, C 1-6 monoalkylamino: Y and Z are SHO, S: R 1 , R 2 and R 3 are H, C 1-6 alkyl, (substituted) C 6. -10 aryl: D and B represent the residues of the following β group. However, k = When 0, m = 0. The nucleotide sequence containing B is complementary to the oncogene or viral gene. [Β group] Adenine, guanine, cytosine and thymine. [Effect] The compound of the general formula (I) is an antisense nucleic acid derivative and is useful as an active ingredient of an antiviral agent and an antitumor agent. |