| abstract |
(57) [Summary] (Modified) [Constitution] General formula I: (R 1 and R 2 are hydrogen, alkyl, alkenyl, hydroxyalkyl, alkoxyalkyl, aralkyl, aryl or aminoalkyl, each of R 3 and R 5 is H or CF 3 , but only one of R 3 or R 5 Is CF 3 And each of R 4 and R 6 is H or CF 3 However, when either or both of R 4 and R 6 is CF 3 , neither R 3 nor R 5 is CF 3 , and further R Each of 3 to R 6 cannot be H at the same time, and both R 1 and R 2 can be ethyl only when R 4 and R 6 are CF 3 ). EFFECTS It is useful in treating bone wasting diseases, including postmenopausal osteoporosis, which increase bone formation and bone mass in mammals. |