| abstract |
(57) [Summary] [Purpose] To release the diltiazem preparation as a therapeutic agent for chronic heart diseases such as angina and hypertension. [Structure] Diltiazem or a pharmaceutically acceptable salt thereof, and optionally a spheroid-forming substance, A controlled release composition comprising a spheroid core coated with a controlled release layer. The spheroid-forming substance is preferably microcrystalline cellulose. Ethyl cellulose is the preferred controlled release coating material. The controlled release coating preferably contains a plasticizer, a surfactant and a tack modifier. |