| abstract |
(57) [Abstract] [Purpose] Hexapeptide or its pharmaceuticals having inhibitory action on vascular hyperpermeability, anti-edema action, anti-inflammatory action, endothelial dysfunction improving action, antihypertensive action, antiprotease action, anti-DIC action and wound healing action Provide an acceptable salt. [Structure] The hexapeptide of the present invention is represented by the following formula (II) AB-Pro-CDE (II) [wherein A is arginine or lysine whose N-terminal amino group is alkylated, Is arginine, lysine or histidine, Pro is proline, C is tyrosine, tryptophan or phenylalanine, D is valine, isoleucine or leucine, and E is C-terminal carboxyl group -C. OOR * , Valine substituted with -CH 2 OR or -CONHR, shows the isoleucine or leucine (R * Is a C 1 -C 4 alkyl group, R is a hydrogen atom or C 1 -C 4 represents an alkyl group of 4 )]. |