| abstract |
(57) [Summary] [Structure] Formula I: (In the formula, R is an optionally substituted amino group; R 1 is a hydrogen atom or a lower alkyl group; R 2 is a hydrogen atom or a hydroxy protecting group; R 3 is a hydrogen atom, an imino protecting group or an imino substituent; 4 is a lower alkylene group; R 5 is a hydrogen atom or a carboxy protecting group; a wavy line represents a bond having an R or S configuration) or a salt thereof, a method for producing the same, and a preparation containing the same. [Effects] Compound I exerts an excellent antibacterial action against Gram-negative bacteria in vitro, and also has a good pharmacokinetics in vivo, an excellent therapeutic effect on infection, and high chemical and metabolic stability. It is useful as an agent and a germicide. |