| abstract |
(57) [Summary] [Structure] The present invention provides a compound of the following formula (I) and a salt or prodrug thereof: Wherein Q is an optionally substituted residue of an azabicyclic ring system; X represents oxa or thia; Y represents H or hydroxy; R 1 is phenyl or thienyl (either group Optionally halo, trifluoromethyl or C 1-3 substituted) or C 5-7 cycloalkyl; R 2 is halo, trifluoromethyl or C Represents benzyl or C 5-7 cycloalkyl which may be substituted on the benzyl ring with 1-3 alkoxy; R 3 , R 4 And R 5 are independently H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, halo, cyano, nitro, trifluoromethyl, trimethylsilyl, —OR a , SCH 3 , SOCH 3 , SO 2 CH 3 , -NR a R b , -NR a COR b , -NR a CO 2 R b , -CO 2 R a or -CONR a R b ; R a and R b independently represents H, C 1-6 alkyl, phenyl or trifluoromethyl]. [Effect] This compound is a tachykinin receptor antagonist, These and their compositions are therapeutically useful. |