| abstract |
(57) [Summary] (Modified) [Objective] To provide N-substituted heterocyclic derivatives which inhibit the action of angiotensin II, their production and pharmaceutical compositions containing them. [Structure] Formula: [R 1 and R 2 are C 1-6 alkyl, C 3-7 cycloalkyl, phenyl, or phenylalkyl, or R 1 And R 2 together form the formula ═CR ′ 1 R ′ 2 , and the bound R 1 and R 2 are further represented by the formula — (CH 2 ) n—, the formula — (C H 2 ) pY (CH 2 ) q- or the like; and R 3 represents hydrogen, C 1-6 alkyl, phenyl, phenylalkyl, or the like; R 4 represents a (substituted) benzyl group, benzyloxy, or the like. Group, benzoyl group, phenylamino group, etc .; X represents O, S; Y is CH substituted with O, S or a C 1-4 alkyl group; p + q = m; m = 2-5; n = 2 to 11; R 1 ′ and R 2 ′ are C 1-4 alkyl group, phenyl group and the like; z and t are 0, or one is 0 and the other is 1] A salt thereof, a method for producing the salt, and a pharmaceutical composition containing the salt. |