| abstract |
(57) [Summary] [Structure] Purified from fetal bovine cartilage, the molecular weight is about 2 The chondromodulin protein (ChM) consisting of 120 or 121 amino acids at 6,000 daltons and its cDNA were separately obtained, and the gene was incorporated into an expression vector to produce ChM in heterologous cells. [Effect] Since ChM has a chondrocyte proliferation action and a vascular endothelial cell proliferation inhibition action, it is useful as a therapeutic agent for bone fractures and various cartilage diseases, and as a therapeutic agent for tumors such as cancer. |