| abstract |
(57) [Summary] [Object] The present invention relates to a novel fluorine derivative of vitamin D 3 , and more specifically, the present invention has an excellent pharmacological action, particularly, a cell from a tumor cell (such as colon cancer cell) to a normal cell. It is intended to produce a novel fluorine derivative of vitamin D 3 having an antitumor activity by a differentiation inducing action, and a cell differentiation inducer containing the compound as an active ingredient. The compounds of the present invention have the general formula: (However, in the formula, R 1 , R 2 and R 3 are each a hydrogen atom, A fluorine-containing vitamin D 3 analog compound represented by a chemically inactive hydroxyl-protecting group, an acyl group having 2 to 8 carbon atoms or an alkyl group having 1 to 8 carbon atoms, and n is an integer of 4 to 6). is there. |