| abstract |
(57) [Summary] (Modified) [Purpose] To provide psychotropic substances with few side effects. [Structure] A novel imide derivative represented by the general formula shown or an acid addition salt thereof. [The D in the formula - (CH 2) p -A- ( CH 2) q - divalent group (here represented by, A is a lower alkylene group or a hydrocarbon ring, p, q are each 0, 1 or 2); G is N, CH or COH; Ar is an aromatic heterocyclic group (3-benzisothiazolyl, 3-benzisoxazolyl, 3-isoquinolinyl, 8-quinolinyl, 2-pyridine, 7-benzofuryl etc.), aromatic hydrocarbon groups (substituted phenyl, naphthyl etc.) benzoyl, phenoxy) etc .; Z represents a cyclic imide group represented by the formula. (In the formula, B represents CO or SO 2. R 1 , R 2 , R 3 , R 4 represents a hydrogen atom or lower alkyl. However, R 1 and R 2 or R 1 and R 3 may be combined to form a hydrocarbon ring. n represents 0 or 1)] [Effect] This imide derivative is useful as a therapeutic drug for schizophrenia, senile psychiatric disorders, depression, neuropathy and the like. |