| abstract |
(57) [Summary] (Modified) [Object] To provide a diaminotrifluoromethylpyridine derivative or a salt thereof useful as a phospholipase A 2 inhibitor, an anti-inflammatory agent and an anti-pancreatitis agent. [Structure] General formula (I) (X is -CW 1 R 1 group, -COCOR 2 group, -CW 1 N HCOR 2 group, -C (= W 1 ) W 2 R 3 group or -CW 1 N (R 4 ) R 5 group, Y is an alkyl group, —CW 3 R 6 group, -COCOR 7 group, -NHCOR 7 group, -C (= W 3) W 4 R 8 group, - (NH) m SO 2 R 9 group, - (NH) m SO 2 OR 10 group or - (NH) m SO 2 N (R 11) R 12 group) or a salt thereof, a method for producing them, a phospholipase A 2 inhibitor containing them, an anti-inflammatory agent and an anti-pancreatitis agent, and a novel trifluoromethylpyridine derivative as an intermediate. A specific example of formula (I) is N- (2-ethylsulfonylamino-5-trifluoromethyl-3-pyridyl) pentafluoropropionamide. |