http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H05163276-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d202e9e866984fe229f6facc38f1d740 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N43-90 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P33-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P33-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N43-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-01 |
| filingDate | 1992-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_29901a951710a2eb68c3a14ee43ed413 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_449365ffa925ccf81ef3213d6fa2313e |
| publicationDate | 1993-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H05163276-A |
| titleOfInvention | Method for inverting the C13 stereochemistry of avermectin aglycone compounds |
| abstract | (57) [Summary] (Modified) [Purpose] To rearrange or epimerize the natural stereochemistry at position 13 of avermectin aglycone, which is usually below the α-direction or molecular plane, to β position. [Structure] An avermectin aglycone compound (formula 2) substituted with a leaving group by acylating a 13α-hydroxy compound (formula 1), and treating the substituted compound with tetraalkylammonium nitrate, the leaving group is substituted, Hydroxy is substituted with a nitrate ester or a nitrooxy group to give 13- Stereochemistry rearranges to β (compound of formula 3). When the nitrooxy group is reduced, it returns to 13-hydroxy group and 13-β- A hydroxy form (compound of formula 4) is obtained. [Effect] This method is simple and has a high yield, and the intermediate 13-nitrooxy compound (formula 3) is itself a powerful antiparasitic agent. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2013545485-A |
| priorityDate | 1991-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 89.