| abstract |
(57) [Summary] (Modified) [Purpose] Interleukin-1 production inhibitory action or / And a novel imidazole derivative having a secretion inhibitory action and useful as a therapeutic agent for inflammatory diseases. [Constitution] The following formula [1] (In the formula, A is a lower alkylene group, B is an aromatic hydrocarbon ring or a thiophene ring, D is a single bond, an oxygen atom, -CO- , R 1 is a hydrogen atom or a halogen atom, and R 2 is A lower alkyl group, a lower alkenyl group, an optionally substituted phenyl group, an optionally substituted cycloalkyl group, or an optionally substituted thienyl group, and When D represents a single bond, R 2 represents a lower alkoxy group or a hydroxy group. R 3 represents a nitrogen atom-containing heterocyclic group, and R 4 represents a hydrogen atom or a lower alkyl group.) The imidazole derivative represented by or its acid addition salt. The following compounds are given as specific examples. |