| abstract |
(57) [Summary] (Modified) [Purpose] Has a strong angiotensin II antagonism, Disclosed is a novel nitrogen-containing heterocyclic compound useful as a therapeutic agent for cardiovascular diseases such as hypertension, heart disease and stroke. [Structure] A compound represented by the formula (I), or a salt thereof. [In the formula, Z is a group of the structural formula shown in the figure, which is bonded to a ring nitrogen atom, Y is N or CH, and X is two phenylene groups bonded through a spacer having 2 or less atoms. .. As a compound represented by the formula (I), those of the formula (I ′) are particularly mentioned. In the formula (I ′), R 1 is C 1-4 Such as an alkyl group, R 2 and R 3 represent hydrogen, a (substituted) alkyl group, or R 2 -R 3 to form a benzene ring, and R 4 and R 5 represent hydrogen and a tetrazolyl group] |