| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a717ea5b2ac78ac329ab3a9659d834d2 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C69-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-10 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-416
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-472
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D221-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-26 |
| filingDate |
1992-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_070cfe939c6a6f55b6fa962b75e53b0f |
| publicationDate |
1993-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-H05148264-A |
| titleOfInvention |
Process for producing spiro [isoquinoline-4 (1H), 3'-pyrrolidine-1,2 ', 3,5' (2H) -tetron useful as an aldose reductase inhibitor and intermediates thereof |
| abstract |
(57) [Summary] (Modified) [Purpose] Providing a method for producing spiro-isoquinoline pyrrolidine. [Structure] A method for producing a compound represented by the formula (I) using 2-bromo (or chloro) benzoic acid (s) represented by the formula (II) as a starting material, and a formula obtained and utilized by this method. Intermediate compound of (V). [Wherein R 1 represents hydrogen or halogen; R 2 represents dihalogen-substituted benzyl or methyl] [Effect] This method is useful as an aldo-reductase inhibitor spiro [isoquinoline-4 (1H), 3'-pyrrolidine ] It is an improved method useful for the synthesis of -1,2 ', 3,5' (2H) -tetron. |
| priorityDate |
1991-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |