| abstract |
(57) [Summary] (Modified) [Objective] To provide a novel benzoxazinone derivative having anti-inflammatory activity and protease inhibitory activity. [Structure] General formula [Wherein R 1 , R 2 , and R 3 are hydrogen atoms or lower alkyl groups; A is a (halogen-substituted) phenyl group, a heterocycle such as pyridine or an adamantyl group; B is a hydrogen atom, a (halogen-substituted) phenyl group Or a heterocycle such as pyridine; U = C H -, = C = or = N-; V is -O -, - CH 2 -, = N-, -NH-, -CH = or a single bond; X is -O-, = CH -, - CH 2 - or a single bond; Y is -CH 2 -, - NH -, - O-or a single bond; Z is -CO- or -CH 2 -; And 1 is an integer of 0 to 3] or a pharmaceutically acceptable acid addition salt thereof, an anti-inflammatory agent and an anti-neutrophil infiltration containing the compound as an active ingredient. Inhibitors and serine protease inhibitors. |