| abstract |
(57) [Summary] (Modified) [Objective] To provide a novel calcium inhibitor having a remarkable and long-term hypotensive effect. A compound represented by the formula (I), an acid addition salt thereof, a method for producing the compound represented by the formula (I), and an active ingredient selected from the compound and a pharmaceutically acceptable acid addition salt thereof. A therapeutic composition containing: (In the formula, Ar is 2-nitrophenyl, 3-nitrophenyl, 2-chlorophenyl, 2,6-dichlorophenyl, Represents a group selected from a 2-trifluoromethylphenyl group and a 3-trifluoromethylphenyl group, R 1 is C 1 -C 4 alkyl group or a group -A- (CH 2) 3 -CO- R 2 , A is any of the groups shown, and R 2 is 2, Represents 4,6-trimethoxyphenyl, 2-thienyl or phenyl) |