| abstract |
(57) [Summary] (Modified) [Objective] To provide a substituted pyridine derivative useful for the treatment of glaucoma. [Structure] A pyridine derivative in which a pyridine ring is substituted with a substituent of an azani cyclic ring represented by the general formula (I) or a pharmaceutically usable salt thereof is used for treating glaucoma and / or reducing intraocular pressure. A method for use in the manufacture of a medicament for use, and a pharmaceutical composition containing the derivative, which is suitable for treatment of ocular hypotension and / or glaucoma. [In the formula, R 2 and R 11 are hydrogen, halogen, CF 3 and OR. 6 , NR 6 R 7 , CN, COR 8 and the like; R 6 , R 7 are hydrogen and C 1-6 alkyl; R 8 is OR 6 , NR 6 R 7 ; and R 1 represents the illustrated cyclic group. However, in the figure, the broken line represents an arbitrary chemical bond, R 3 and R 4 represent hydrogen, C 1-4 alkyl, C 1-4 alkoxy, etc., and R 5 Represents hydrogen, C 1-4 alkyl, or R 3 and R 4 together represent carbonyl] |