| abstract |
(57) Summary (with modifications) A compound which is a leukotriene biosynthesis inhibitor having formula I or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of a compound of formula I A pharmaceutical composition containing the same. Wherein, X 2 -X 3 is O-CH 2, S-CH 2, CH = CH, CH 2 CH 2 ; R 1 , R 2 are H, Cl, CN, C F 3 , CH 3, etc. (especially R 2 = H); R 3 , R 4 are H, F, CH 3 , SO 2 CH 3, etc. (especially R 4 = H); R 5 is (substituted) benzyl, methyl, acetyl, etc .; R 7 is —CH 2 -COOH, -COOH, etc.; (R 6 CR 6) p is (C H 2 ) m (m = 2, 3, 4); (R 6 CR 8 ) q is methylene, (substituted) benzylidene or the like, and P + q is 3 to 5. [Effects] The compound of the present invention is useful as an anti-asthma agent, an anti-allergic agent, an anti-inflammatory agent and a cytoprotective agent, and also has diarrhea, hypertension, angina, platelet aggregation, cerebral convulsion, preterm labor, spontaneous abortion, It is useful for treating dysmenorrhea and migraine. |