| abstract |
(57) [Summary] (Modified) [Purpose] To provide a leukotriene biosynthesis inhibitor comprising a 5-hydroxy-2,3-dihydroxybenzofuran analog. [Constitution] The following formula (I) [In the formula, R 2 is R 3 is hydrogen or C 1-6 alkyl, R 5 is hydroxy or a group metabolizable to hydroxy, R 4 and R 6 are hydrogen, Halogen, a C 1-6 alkyl, R 7 is hydrogen, halogen, C 1-6 alkyl, or C 2-6 alkenyl, A 2 Represents a substituted phenyl, a substituted naphthyl, a substituted or unsubstituted heterocycle, etc., and P represents 0 or 1.]. [Effects] The above compounds are asthma, allergy-like symptoms, It is a useful therapeutic agent for treating cardiovascular disorders such as angina and inflammation, for ameliorating skin diseases such as psoriasis and atopic diseases, and as a cell protective agent. |