| abstract |
NEW MATERIAL:The peptide of formula I (X is Leu or Phe; Y is Ser or Ala; Z is Val or Leu) or its salt. EXAMPLE:The peptide of formula II. USE:Useful as a hypotensor, etc., having ileum constriction action, canine mesenteric artery relaxing action, angiotensinase inhibiting action, etc. PREPARATION:The objective peptide can be produced e.g. by decomposing serum albumin with trypsin, deactivating the enzyme, centrifuging the product, subjecting the obtained supernatant to reversed-phase high-performance liquid chromatography (HPLC) with octadecylsilyl column, eluting with acetonitrile containing 0.1% trifluoroacetic acid under a linearly varying concentration gradient and finally purifying the obtained active fraction by HPLC treatment using a phenyl column and a cyanopropyl column. |