http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H0495075-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6cfc033f059d282fcd915bc8be2ae53f |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-20 |
| filingDate | 1990-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_14a51079338b090eb57667a47fe249d1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_11ff8866adf58b6dd97384f74cc9ce12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0be2f9fa11c102dae5f0f9779a268380 |
| publicationDate | 1992-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H0495075-A |
| titleOfInvention | Production of 5-hydroxyquinoline |
| abstract | PURPOSE: To easily obtain the subject compound useful as a synthetic intermediate for pharmaceuticals at a low cost by treating 5-aminoquinoline with sodium bisulfite and an alkaline aqueous solution. n CONSTITUTION: The objective hydroxyquinoline can be produced by dissolving 5-aminoquinoline in an aqueous solution of sodium bisulfite, refluxing the mixed solution for 2-48hr under normal pressure until the raw material is almost consumed, adding an alkaline aqueous solution (e.g. aqueous solution of NaOH) and refluxing under heating for 2-3hr. The amounts of the sodium bisulfite and the alkaline aqueous solution are preferably 5-10 pts. and 10-20 pts. per 1 pt. of the 5-aminoquinoline, respectively. The 5-hydroxyquinoline is useful as a raw material for pharmaceuticals such as a circulatory drug called as β-blocker or a carcinostatic agent. n COPYRIGHT: (C)1992,JPO&Japio |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2005247727-A |
| priorityDate | 1990-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 25.