| abstract |
NEW MATERIAL:Compounds of formula I (R 1 is heterocyclic group; R 2 is H, lower alkyl or hydroxyl-protecting group; R 3 is H or lower alkyl; n R 4 and R 5 are H or lower alkyl; R 6 is amino, nitrogencontaining heterocyclic group or ammonio; n is 0-6). n EXAMPLE: Hydrochloride of 1-(benzo[b]thiophen-5-yl)-2-[2-N,N-dimethylamino) ethoxy]ethanol. n USE: A remedy for brain function useful for remedy of cerebrovascular dementia, senile dementia, Alzheimer's disease, aftereffects of ischemic encephalopathia, cerebral apoplexy, etc. n PREPARATION: A compound of formula II is reacted with a compound of formula III in a solvent such as benzene, as necessary in the presence of a base (e.g. NaOH) at 20-150°C to obtain the objective compound of formula I. n COPYRIGHT: (C)1992,JPO&Japio |