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filingDate 1990-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_727ba47ab35646b09d1e56318e94c21c
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publicationDate 1992-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-H0477499-A
titleOfInvention Physiologically active peptide having heparin-binding property
abstract PURPOSE: To obtain the title physiologically active substance improved in stability in blood circulation system and enhanced antihypertensive activity while lowering only diuretic effect by binding a heparin-binding peptide to human atrial sodium diuretic hormone. n CONSTITUTION: The objective physiologically active substance obtained by binding a heparin binding peptide to a human atrial sodium diuretic hormone (hANP). The physiologically active substance is obtained by binding a heparin- binding peptide, e.g. consisting of heparin binding region, etc., of antithrombin III to hANP using a crosslinking reagent such as N-(ε-maleimidecaproyloxy)- succinimide. n COPYRIGHT: (C)1992,JPO&Japio
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-5799409-B2
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