http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H0469386-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eebd94dd108d74a49ab9415252e5e281 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4162 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-407 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 |
| filingDate | 1990-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_44156a1962b43e55c8f278087e978ade http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d448c9c419de4f60739c4b05ef678b46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_75644eab541fe6004474de719e767109 |
| publicationDate | 1992-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H0469386-A |
| titleOfInvention | Bicyclic gamma-lactam derivative |
| abstract | NEW MATERIAL:A compound shown by formula I (R 1 is H or lower alkyl; R 2 is H or anion charge; R 3 is aminoethyl, 4-pyrazolidinyl, etc.). n EXAMPLE: (5S,7S)-3-Aminoethylthio-7-[(1R)-hydroxyethyl]-8-oxo-1-a- zabicyclo[3,3,0]oct-2-ene-2-carboxylic acid. n USE: An antimicrobial agent. n PREPARATION: For example, a 2-(1-hydroxyethyl)-3-formylpropanamide derivative shown by formula II is subjected to ring closure reaction to give a 2- pyrrolidinone derivative, which is reacted with an N-acyl-1,3-thiazolidine-2-thione derivative to give a compound shown by formula III (R 6 is ethyl or isopropyl). Then, 1,3-thiazolidine-2-thione ring is subjected to ring opening, made into an azide derivative and subjected to ring closure to give an azabicyclo compound, which is oxidized to give a compound shown by formula IV (R 21 is alkyl, etc.), which is then treated with a mercapto compound and hydroxyl protecting group is eliminated to give a compound shown by formula I. n COPYRIGHT: (C)1992,JPO&Japio |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H0240565-U |
| priorityDate | 1990-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 35.