| abstract |
PURPOSE: To obtain an aldol reductase inhibitor which contains a specific compound as an active ingredient, thus being useful in prevention and treatment for diabetic complication. n CONSTITUTION: The inhibitor contains, an active ingredient, a compound of formula I or formula II (R 1 - R 5 are H, halogen, or alkyl, alkenyl, aryl or aralkyl where a part or all of the hydrogen atoms are substituted with halogen atoms). The compound of formula I is prepared by dihydroxylation, etherification and carbon atom-increasing reaction of an ortho-substituted benzoic acid to give 3-(4,6-dihydroxy-0-toluyl)butane-2-ol followed by carboxylation, Gattermann reaction and intramolecular dehydration of the product. The compound of formula II is obtained by reduction of the compound of formula I. n COPYRIGHT: (C)1992,JPO&Japio |