| abstract |
PURPOSE: To provide a low toxic arteralization-inhibiting agent containing a herbimycin derivative as an active ingredient. n CONSTITUTION: The objective agent contains a compound of formula I (R 1 , R 2 are Cl, or both are bonded to each other, when R 1 , R 2 are Cl, R 3 and R 4 , R 5 and R 6 both are bonded to each other, R 7 , R 8 are H; when R 1 and R 2 are bonded to each other, R 3 is OCH 3 , Cl, R 7 is H, group of formula II, R 3 is H, Br, R 4 is OCONH 2 , R 5 and R 6 form O or a bond together, or R 4 and R 5 form O-CO-O together and R 6 is Br) as an active ingredient. The compound is useful for preventing or treating various diseases caused by the abnormal multiplication of blood vessels, such as rheumatic arthritis, diabetic retinopathy, immature baby retinopathy, senile macular degeneration and excessive cicarrix formation when wound is healed. n COPYRIGHT: (C)1992,JPO&Japio |