| abstract |
PURPOSE: To obtain a new amino acid derivative and its salt useful for controlling, etc., of diseases caused by retrovirus such as AIDS and cardiac, circulatory and vascular diseases, especially, hypertension, cardiac failure and aldosteronism. n CONSTITUTION: Amino acid derivative or its salt of the formula [X is H,R 9 -O- C m -H 2m -CO, etc.; R 1 , R 2 , R 7 -R 9 are each H, an alkyl, an Ar (Ar is phenyl, etc.), an Ar-alkyl, etc.; R 3 is (H, OH), (H, NH 2 )=O; R 4 , R 5 are each H or an alkyl; R 6 is an Ar-alkyl or a cycloalkyl; W is O or NH; (a) is 2 or 3; (m) is 0-10; (n), (p) are each 0-3], e.g. BOC-Phe-β1a-ABHP-Ile-AMPA, is prepared, for example, by treating one of functional derivatives of the compounds of formula I with a reagent for solvolysis or hydrogenolysis. n COPYRIGHT: (C)1992,JPO |