| abstract |
PURPOSE: To prepare a therapeutic agent for disorders of cognitive functions such as presenile dementia, senile dementia, memory dysfunctions, deteroration of awareness and especially Alzheimer's disease. n CONSTITUTION: This therapeutic agent for disorders in the central nervous system comprises at least one of a compound represented by the formula {(n) in an integer of 1-6; R is H, a halogen, a 1-4C alkyl, a heteroaryl, SO 3 H, an N-substituted or an N,N-disubstituted sulfamoyl, NO 2 , OH, oxo, a 1-4C alkyoxy, CN, a 1-4C alkylcarboxylate, an aryl, a substituted aryl or NR 1 R 2 [R 1 and R 2 are each H, R 3 , COR 3 or SO 2 R 3 (R 3 is a 1-4C alkyl or an aryl]} and its pharmaceutically permissible salt, e.g. 1-{4-[4-(2-pyrimidinyl)-1- piperazinyl]butyl}-1H-pyrazole as an active ingredient. The daily dose of the active ingredient in treatment of humans is preferably about 5-100mg and the derivetive can be administered by various methods, especially preferably by the oral administration. n COPYRIGHT: (C)1992,JPO |