| abstract |
PURPOSE: To obtain a leukotriene antagonistic agent, containing a partially new 2,4-diamino-1,3,5-triazine derivative as an active ingredient and useful as a therapeutic and preventive agent for allergic, inflammatory, cardiovascular diseases, etc. n CONSTITUTION: A leukotriene antagonistic agent containing a partially new compound expressed by formula I (X and Y are H or acyl; R is substituted or unsubstituted phenyl, phthalidylmethyl or AR 1 ; A is CH 2 CH 2 or CH=CH; R 1 is substituted or unsubstituted phenyl, naphthyl or pyridyl) or its pharmaceutically permissible salt, e.g. 2,4-diamino-(E)-6-[2-(3-pyridine) ethenyl]-3,5-triazine expressed by formula II as an active ingredient is obtained. The aforementioned compound can orally or parenterally be administered. In the case of the oral administration, the above-mentioned compound is normally preferably administered in a dose of 0.2-25mg/kg body weight expressed in terms of the aforementioned compound for an adult per day in several divided portions. n COPYRIGHT: (C)1992,JPO&Japio |