http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H04299994-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_44c713790ce00813da2e6c6d57a29456 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-66 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 |
| filingDate | 1991-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5852e57c3e12a8adc96404736577e041 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f906db867d3e73de1e05367db49ac8d4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b80b6342c666b7915fab011390cab231 |
| publicationDate | 1992-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H04299994-A |
| titleOfInvention | Production of optically active 1,4-dihydropyridine compound |
| abstract | PURPOSE: To specifically obtain the title compound usable for prevention and treatment for angina pectoris, hypertension, etc., by acting an enzyme capable of subjecting either one of two carboxylic acid esters of a specific 1,4- dihydropyridine compound to asymmetric ester interchange reaction on the specific 1,4-dihydropyridine compound. n CONSTITUTION: An enzyme having ability capable of subjecting either one of a carboxylic acid ester bound to 3- and 5-position of 2,6-dimethyl-4-(3- nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid bis(2-nicotinoylaminoethyl) ester or salt thereof to asymmetric ester interchange reaction is acted on the above-mentioned ester or salt thereof in the presence of 3-nitroxypropyl alcohol and then the resultant product is purified by a silica gel column chromatography to provide the objective optically active (-)-2,6-dimethyl-4-(3-nitrophenyl)-1,4- dihydropyridine-3,5-dicarboxylic acid 3-(2-nicotinoylaminoethyl) ester-5-(3- nitrooxypropyl)ester. n COPYRIGHT: (C)1992,JPO&Japio |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9405637-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5635395-A |
| priorityDate | 1991-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 24.