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filingDate 1991-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2626e5e21e0ed5e0a2a1f32d339745a0
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publicationDate 1992-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-H04282348-A
titleOfInvention Preparation of arylalkylamine and substituted arylalkylamine
abstract PURPOSE: To cost effectively and efficiently produce substd. and unsubstd. arylalkylamines (for examples, tyramine and its deriv.) which are pharmacologically and physiologically important drugs. n CONSTITUTION: The substd. or unsubstd. arylalkylketone is brought into reaction with lower alkyl sulfite ester in the presence of hydrogen chloride in a bipolar aprotic solvent and thereafter, the reaction mixture is extracted with the ester or alcohol of the lower alkyl by adding water thereto, by which the extract contg. aryl-α-oxyminoalkylketone is obtd. The extract is converted from the arylalkylketone to the arylalkylamine by hydrogenation using hydrogen in the presence of a hydrogenation catalyst in a nonaq. reaction medium consisting of the greater part of carboxylic acid (for example, acetic acid) and the small part of an inorg. strong acid (for example, sulfuric acid). n COPYRIGHT: (C)1992,JPO
priorityDate 1990-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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