http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H04273875-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2ca2e4410855da087e11bf3eea8933fa |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D463-00 |
| filingDate | 1991-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5024b837a009872b7ec2edf554fb2dba |
| publicationDate | 1992-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H04273875-A |
| titleOfInvention | Cleavage of ester group of cephalosporins |
| abstract | PURPOSE: To cleave ester group mildly in one step with minimum decomposition of cephalosporins bringing a specific substrate into contact with lithium iodide in the reaction mixture which contains a substantial concentration of acetonitrile. n CONSTITUTION: The compound of formula II (X is CH 2 or S; R 1 is H or an amino protecting group, etc.; R 2 is Cl, Br or methyl; R 3 is H or a 1-4C alkoxy, etc.) is obtained by bringing the substrate of formula I (R 4 is methyl or ethyl) into contact with lithium iodide in the reaction mixture which contains a substantial concentration of acetonitrile. The amount of lithium iodide to be added is 2-7 mole per mole of objective product, and the solvent used for reaction is comprised of 0-20% of an aprotic solvent and 80-100% of acetonitrile. n COPYRIGHT: (C)1992,JPO |
| priorityDate | 1990-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 28.