http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H04267890-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_25cabd848a625c278d0f654e54a2f0c0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dfd617dc43a4c986d2dd81e4cb39d9dd |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P41-00 |
| filingDate | 1991-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6836bbe1356780b142d6406a925e9156 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c8963a149a0dd762d332b0da3cc6cbc9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bebda06f0f7c7a4bdee87bf3f86dfafc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ea8c8187d896dc5fa1f402548fd58ee2 |
| publicationDate | 1992-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H04267890-A |
| titleOfInvention | Production of (r)-2-propoxybenzene derivative |
| abstract | PURPOSE: To obtain the subject compound useful as a synthetic intermediate for a pyridobenzoxazine derivative known as a synthetic antibacterial agent in high purity under mild condition by carrying out the asymmetric acylation of a hydroxypropoxybenzene derivative in the presence of an esterase. n CONSTITUTION: An (R)-2-acyloxypropoxybenzene derivative of formula II [-C(0)R 1 is organic acyl] is produced by reacting a (I)-2-hydroxypropoxybenzene derivative of formula I (X 1 and X 2 are halogen), e.g. (±)-2,3-difluoro-6-nitro[(2- hydroxypropyl)oxy]-benzene with an acylation agent consisting of an organic carboxylic acid (preferably acetic anhydride, etc.) in the presence of an esterase. The hydrolysis of the compound of formula II gives an (R)-2- hydroxypropoxybenzene derivative of formula III. The acylation of the compound of formula I is preferably carried out in an ether solvent at 20-50°C. n COPYRIGHT: (C)1992,JPO&Japio |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02079485-A1 |
| priorityDate | 1991-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 35.