| abstract |
PURPOSE: To provide the novel compd. which exhibits high α-glucosidase inhibition activity and is effective for suppression of an increase in blood glucose and for prediabetes, diabetes, obesity, adiposis, etc., and its pharmaceutically permissible bases. n CONSTITUTION: The novel α-glucosidase inhibitive material described as the pradimicin Q expressed by the formula and its pharmaceutically permissible bases. The compd. of the formula is obtd. by culturing the pradimicin Q productive strain (the strain selected from R103-3 strain, i.e., ACCNo. 53930 and A10102 strain, i.e., ATCCNo. 55092 is used) of Actinomadura-verrucospora subsp. neohibisca under the conditions of air permeation in the deep part in the medium including the metabolizable sources of carbon and nitrogen and recovering the compd. of the formula from the medium. n COPYRIGHT: (C)1992,JPO |