http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H04257584-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bb66d9373d09efad73c142762f6dfb00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2e5edd48190cba3fa70dd3975efd9831 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-99 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 |
| filingDate | 1991-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1deff904294983e4108e88298c20a8af http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a6ee321f15d189803883ea119821b9dc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d2d8e5845a9150a87fd8af31fb4f77db http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a7e29738e2d340cdad1fe5bd1c29fbce http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_59469e6eab03935c8444a25be43115a2 |
| publicationDate | 1992-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H04257584-A |
| titleOfInvention | 5,11-dihydro-6h-dipyrid(3,2-b:2',3'-e)(1,4)diazepine and composition for prevention or treatment of hiv infection containing this compound |
| abstract | PURPOSE: To provide a compd. which suppresses the enzymatic function of an HIV-1 reverse transcriptase and is useful for the prevention and treatment of a human HIV-1 infection. n CONSTITUTION: The compd. of formula I (R 1 is H, 1 to 6C alkyl, etc., when Z is O, S, NCN, etc.; R 2 is H, and when R 1 is not H, 1 to 6C alkyl, etc.; R 3 to R 5 are H, or one thereof is 1 to 6C alkyl, 2 to 6C alkenyl, etc., and the other two substituents are H, methyl, etc., or two are 1 to 2C alkyl, halogen, etc., and the remaining one is H, methyl; R 6 to R 8 are H or one is 1 to 4C alkyl, 2 to 4C alkenyl and the two substituents are H, etc.), and the pharmaceutically permissible acid additive salts. For example, 11-cyclopropyl-5,-11-dihydro-4- methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepine-6-on or -4 on. The compd. of the formula I is obtd. by bringing the compd. of formula II (R 2 ' is the same as R 2 exclusive of H; Hal is F, Cl, Br, I) into reaction at 110 to 220°C by adding a catalyst thereto in an inert solvent and bipolar nonprotonic soln. in the presence of a metal chlorinating agent. n COPYRIGHT: (C)1992,JPO |
| priorityDate | 1990-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 28.