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filingDate 1991-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b6e6e5b011bd3d700d559c74e6cb2033
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publicationDate 1992-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-H04257563-A
titleOfInvention Tricyclic heterocyclic derivative, its production and medicinal pharmaceuticals containing this compound and having anticancer action
abstract PURPOSE: To provide the novel tricyclic heterocyclic deriv. which has anticancer action by the interaction with a topoisomerase enzyme or its salts and hydrolyzable esters. n CONSTITUTION: The compd. of formula I (A is a (substd.) benzene ring, pyridine ring; R 1 , R 2 are 1 to 4C alkyl, 1 to 4C alkoxy; R 3 is H, 1 to 4C alkyl, 1 to 4C alkoxy); for example, 3-chloro-10-(4-hydroxy-3,5-dimethoxybenzyl)-9,10- dihydroacrydine-9-on. This compd. is obtd. by coupling the compd. of formula II and the compd. of formula III (Z is a substitutable group). The coupling reaction is executed at -10 to 150°C in a solvent, such as DMF, in the presence of a base (e.g.; sodium hydroxide). n COPYRIGHT: (C)1992,JPO
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type http://data.epo.org/linked-data/def/patent/Publication

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Total number of triples: 30.