abstract |
PURPOSE: To provide the novel tricyclic heterocyclic deriv. which has anticancer action by the interaction with a topoisomerase enzyme or its salts and hydrolyzable esters. n CONSTITUTION: The compd. of formula I (A is a (substd.) benzene ring, pyridine ring; R 1 , R 2 are 1 to 4C alkyl, 1 to 4C alkoxy; R 3 is H, 1 to 4C alkyl, 1 to 4C alkoxy); for example, 3-chloro-10-(4-hydroxy-3,5-dimethoxybenzyl)-9,10- dihydroacrydine-9-on. This compd. is obtd. by coupling the compd. of formula II and the compd. of formula III (Z is a substitutable group). The coupling reaction is executed at -10 to 150°C in a solvent, such as DMF, in the presence of a base (e.g.; sodium hydroxide). n COPYRIGHT: (C)1992,JPO |