| abstract |
PURPOSE: To obtain the objective bicyclo[4,1,0]heptane-2,4-dione derivative having a steric configuration by using a new bicyclo[4,1,0]heptane-2,4-dione derivative as a starting raw material. n CONSTITUTION: A compound [e.g. cis-5-ethoxycarbonylbicyclo[4,1,0]heptane-1,4- dione] shown by formula I or formula II [R 1 and R 2 are H, alkyl or COOR 4 (R 4 is alkyl) is made to react with a compound (e.g. 2-nitro-4- methanesulfonylbenzoic acid chloride) shown by the formula XC(=O)R 3 [R 3 is alkyl, (substituted)phenyl, (substituted)aralkyl or (substituted)heterocyclic ring; X is halogen, OCOR 5 or OCOOR 6 (R 5 are R 6 are alkyl or phenyl)] to give a compound [e.g. cis-3-(2-nitro-methanesulfonylbenzoyl)-5-methyl-5- ethoxycarbonylbicyclo[4,1,0]heptane-2,4-dione] shown by formula III or formula IV. n COPYRIGHT: (C)1992,JPO&Japio |