| abstract |
PURPOSE: To obtain a new tricyclic pyridone derivative useful for controlling or preventing musclar tension, suppression and sleeplessness, etc. n CONSTITUTION: This compound of the formula I or its pharmasceutically acceptable acid added salt of the compound of the formula I having basic substituted group, e.g. N,N-dimethyl-4,6-dihydro-4-oxo-3-phenylpirido [2,1-a] isoindole-1- carboxyamide is obtained preferably by converting the carboxylic acid of the formula II to an active derivative and then allowing it to react with the compound denoted by the formula R'OH. In the formula I, Ra is H, halogen; Rb is OR 1 (R 1 is non-substituted lower alkyl, hydroxy, etc.), HR 2 R 3 (R 2 is H, hydroxy, etc.; R 3 is H, lower alkyl, etc.); C denoted by B, α is >C α -S-CH≡CH-, >C α -CR 4 =CH-CH=CH-, (R 4 is H, F, etc.). In the formula II, C denoted by β, α is >C α -S-CH=CH-, >C α -CH=CH-CH=CH-. n COPYRIGHT: (C)1992,JPO |