| abstract |
PURPOSE: To provide the title new, biologically low toxic derivative giving high inhibitory activity to aldose reductase, useful as a preventive or therapeutic medicine for diabetic complications. n CONSTITUTION: The objective compound of formula I (R 1 is H or lower alkyl; R 2 , R 3 and R 4 are each H, lower alkyl, halogen, lower haloalkyl, OH or lower alkoxy), for example, ethyl {5-[2-(6-methoxy)naphthyl]tetrazol-1-yl}acetate. The present compound can be obtained by reaction at the boiling point in a solvent such as methanol in the presence of a base (e.g. NaOH) between (A) a tetrazole derivative of formula II and (B) a halogenoacetate of formula Hal- CH 2 -COOR 1 . [5-(1-naphthyl)tetrazol-1-yl]acetic acid and its ethyl ester are excepted out of the present compounds of the formula I. n COPYRIGHT: (C)1992,JPO&Japio |