abstract |
PURPOSE: To prepare the subject preparation capable of releasing regulated amount of encapsulated insulin proportional to the glucose concentration in a body. n CONSTITUTION: This sustained release type insulin preparation having insulin encapsulated in a polymer gel matrix containing glucose soluble boronic acid, is obtained by reacting a copolymer of N-acrylamidophenylboronic acid and acrylamide, with a cross-linking agent such as diglycosylhexanediamine. n COPYRIGHT: (C)1992,JPO |