http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H04235989-A

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filingDate 1991-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_618919934997dff265b12ac4a5ec3097
publicationDate 1992-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-H04235989-A
titleOfInvention Medicine
abstract PURPOSE: To produce a medical composition for treatment of erectile inadequacy of men and sexual arousal disorder of women which contains trans-5-fluoro- tetrahydro-1H-[1,4] benzodioxyno[2,3-C]pyrrole, etc., as its effective ingredients. n CONSTITUTION: (±) Trans-5-fluoro-2,3-dihydro-2,3-bis[(phenylmethoxy)methyl]-1,4- benzoxyne is produced by allowing 3-fluorobenzene-1,2-diol to react with (R, R)-1,4-bis(phenylmetoxy)-2,3-butanediol-bis(4-methylbenzenesulphonate). Then the compound of the purpose which is shown by the formula (R is H, 1-6C alkyl, etc.; R 1 , R 2 are each, H, halogen, 1-9C alkyl, etc.), (e.g. trans-5-fluoro-2,3,3 a,9a-tetrahydro-1H-[1,4]-benzodioxyno [2,3-c]pyrrole, etc.) is obtained by removing the protective group of hydroxy group, methanesulphonating, allowing to react with phenylmethaneamide and by hydrogenating the reaction product. n COPYRIGHT: (C)1992,JPO
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100427127-B1
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