http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H04235986-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5929f2d6f4dba84be8dd3a8ba633db12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 1991-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_89622caad31c0242db2452cb7958c760 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3f4941036f4a8830f6ece9aae59d5ba9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b92f2b95300101f155294eb099c73496 |
| publicationDate | 1992-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H04235986-A |
| titleOfInvention | Pyridopyrimidine derivative, production and use thereof |
| abstract | PURPOSE: To provide a novel pyridopyrimidine derivative exhibiting highly selective toxicity against tumor cells and excellent anti-tumor activity as an anti-tumor agent. n CONSTITUTION: A compound of formula I (A ring is pyridine ring capable of being hydrogenated and of containing one or more substituents; B is divalent ring-like group capable of containing one or more substituents or 2-5C alkylene; X is amino, hydroxyl; Y is H, amino, etc.; COOR 1 , COOR 2 are carboxyl groups capable of being esterified; n is 2-5) or a salt thereof, e.g. 4-[3-(2,4-diamino-5,6,7,8- tetrahydropyrido[2,3-d]pyrimidin-5-yl)propyl] benzoic acid tert-butyl ester. The compound is produced e.g. by acylating a glutamic acid derivative of formula III with a carboxylic acid of formula III in the presence of a dehydration- condensing agent such as dicyclohexylcarbodiimide. The reaction is preferably carried out at a pH of 5-10 at a temperature of 0-50°C. n COPYRIGHT: (C)1992,JPO&Japio |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010149786-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2266984-A1 |
| priorityDate | 1991-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 28.