http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H04234866-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6831b19bfc354357342f7c7da79fc162 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D281-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D281-10 |
| filingDate | 1991-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a0d55c55748677831add9dcf453e0a48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d3eb523e67a760d71f8168d288f7712d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_846793e1e690cf903b76d27047a0c0dc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6bb04878d4d3bf87a875ad667ef6eab0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f7ef75a7eecf5bdf12112893e5a5c3ee |
| publicationDate | 1992-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H04234866-A |
| titleOfInvention | Production of 1,5-benzothiazepine derivative |
| abstract | PURPOSE: To produce a 1,5-benzothiazepine derivative useful as an intermediate for drugs by a process in a high yield by subjecting a propionic acid ester derivative to an intramolecular ring-closing reaction in the presence of a sulfonic acid compound in a specific solvent. n CONSTITUTION: A propionic acid ester of formula I (R 1 is lower alkyl; R 2 is ester residue) is subjected to an intramolecular ring-closing reaction in the presence of a sulfonic acid compound of formula II (R 3 is lower alkyl, phenyl) 10 a non-halogenated organic solvent to produce a 1,5-benzothiazepine derivative of formula III. The compound of formula II is preferably methanesulfonic acid or toluenesulfonic acid. The employment of toluene, ethylbenzene, xylene, n- pentane, etc., as the organic solvent causes the intramolecular ring-closing reaction at 90-160°C, especially 110-145°C. n COPYRIGHT: (C)1992,JPO&Japio |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6197953-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5998637-A |
| priorityDate | 1990-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.